What are painkillers? How do they work in your body?

What exactly are pain relievers?

Painkillers are medications used to treat pain. There are many different types of pain relievers available, each with its own brand name. They are as follows:

  • Through injection.
  • Suppositories are administered through the back canal (rectum).
  • Some pain relievers are also available in the form of lotions, ointments, or patches.

Despite the fact that there are numerous pain relievers available, there are only three major varieties (each of which operates differently). They are as follows:

NSAIDs are nonsteroidal anti-inflammatory medicines. NSAIDs include ibuprofen, diclofenac, and naproxen. Aspirin is another NSAID. However, it is mostly administered (in modest dosages) to assist in preventing blood clotting, such as in persons who have had a heart attack in the past.

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Weak opioids and powerful opioids (also known as opiates). Codeine and dihydrocodeine are two examples of weak opioids. Although they are generally referred to as “weak opioids,” they are incredibly effective analgesics that are frequently used to treat severe pain; however, they can lead to significant addiction and harmful consequences and should not be underestimated. Morphine, oxycodone, pethidine, and tramadol are examples of powerful opioids. Many people who require powerful opioids are hospitalized.

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How do pain relievers work?

NSAIDs function by preventing the action of molecules (enzymes) known as cyclo-oxygenase (COX) enzymes. COX enzymes aid in the production of other compounds known as prostaglandins. Not all NSAIDs are the same, and some work slightly differently than others. For more information, see the companion leaflet Anti-inflammatory Painkillers.

It does not, however, aid with inflammation.

Opioids operate by attaching to opioid receptors in your central nervous system, intestines, and other areas of your body. This reduces the way you perceive pain and your responsiveness to pain while increasing your pain tolerance.

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What is the typical duration of treatment?

Painkillers, like all medicines, should be taken for the shortest time possible and in the lowest amount that relieves your discomfort. This is to assist in avoiding any negative side effects. Most people only need pain relievers for a few days (for example, if they have a toothache) or weeks (if they have torn a muscle).

Some patients, however, have painful ailments that necessitate the use of painkillers on a long-term basis. People suffering from rheumatoid arthritis, osteoarthritis, or persistent back discomfort are examples.

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